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KMID : 0100120050010010005
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Korean Journal of Korean Medical Institute of Dermatology and Aesthetics
2005 Volume.1 No. 1 p.5 ~ p.15
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Effect of the Aqueous Extract of Astragalus membranaceous BUNGE on Melanin Formation in B16 Mouse Melanoma Cell Line
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Kim Young-ok
Lee Eun-Mi
Ahn Duk-Kyun
Shin Jun-Sik
Lee Sung-Hwan
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Abstract
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The purpose of this study was to investigate the effect of the aqueous extract of the Astragalus membranaceous(AM). AM showed inhibitory effect on the tyrosinase activity using L-tyrosine as a substrate. Tyrosinase plays an important role in the process of melanin polymer biosynthesis. In vitro AM extract(1mg/ml) inhibited melanin biosynthesis and are useful for the material used in cosmetics. B16 mouse melanoma cells were cultured in different concentrations. The non-cytotoxicity of the plant extracts was confirmed by MTT assay.
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